Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
Identifieur interne : 001828 ( Main/Exploration ); précédent : 001827; suivant : 001829Therapeutic Options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV) – possible lessons from a systematic review of SARS-CoV therapy
Auteurs : Hisham Momattin [Arabie saoudite] ; Khurram Mohammed [Arabie saoudite] ; Alimuddin Zumla [Royaume-Uni] ; Ziad A. Memish [Arabie saoudite] ; Jaffar A. Al-Tawfiq [États-Unis]Source :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2013.
Descripteurs français
- KwdFr :
- Antiviraux (usage thérapeutique), Essais contrôlés randomisés comme sujet, Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Interféron alpha (usage thérapeutique), Lopinavir (usage thérapeutique), Ritonavir (usage thérapeutique), Résultat thérapeutique, Syndrome respiratoire aigu sévère (traitement médicamenteux), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS.
- MESH :
- traitement médicamenteux : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- usage thérapeutique : Antiviraux, Interféron alpha, Lopinavir, Ritonavir.
- virologie : Infections à coronavirus, Syndrome respiratoire aigu sévère.
- Essais contrôlés randomisés comme sujet, Humains, Résultat thérapeutique, Virus du SRAS.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Humans, Interferon-alpha (therapeutic use), Lopinavir (therapeutic use), Randomized Controlled Trials as Topic, Ritonavir (therapeutic use), SARS Virus, Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (virology), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Lopinavir, Ritonavir.
- drug therapy : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Humans, Randomized Controlled Trials as Topic, SARS Virus, Treatment Outcome.
Abstract
The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections.
Url:
DOI: 10.1016/j.ijid.2013.07.002
PubMed: 23993766
PubMed Central: 7110699
Affiliations:
- Arabie saoudite, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Indiana
- Londres
- University College de Londres
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Le document en format XML
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Memish</name><affiliation wicri:level="1"><nlm:aff id="aff0015">Deputy Minister for Public Health, and Director WHO Collaborating Center for Mass Gathering Medicine Ministry of Health, and Professor, Al-Faisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Deputy Minister for Public Health, and Director WHO Collaborating Center for Mass Gathering Medicine Ministry of Health, and Professor, Al-Faisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation wicri:level="2"><nlm:aff id="aff0020">Specialty Internal Medicine, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia, and Indiana University School of Medicine, Indiana, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Specialty Internal Medicine, Saudi Aramco Medical Services Organization, Dhahran, Saudi Arabia, and Indiana University School of Medicine, Indiana</wicri:regionArea><placeName><region type="state">Indiana</region></placeName></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Humans</term><term>Interferon-alpha (therapeutic use)</term><term>Lopinavir (therapeutic use)</term><term>Randomized Controlled Trials as Topic</term><term>Ritonavir (therapeutic use)</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Interféron alpha (usage thérapeutique)</term><term>Lopinavir (usage thérapeutique)</term><term>Ritonavir (usage thérapeutique)</term><term>Résultat thérapeutique</term><term>Syndrome respiratoire aigu sévère (traitement médicamenteux)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Lopinavir</term><term>Ritonavir</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Randomized Controlled Trials as Topic</term><term>SARS Virus</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Essais contrôlés randomisés comme sujet</term><term>Humains</term><term>Résultat thérapeutique</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East Respiratory Syndrome coronavirus (MERS-CoV) has been detected in a number of countries in the Middle East and Europe with an apparently high mortality rate. It is phylogenetically related to the SARS coronavirus and has also been associated with severe respiratory illness as well as nosocomial transmission in healthcare settings. Current international recommendations do not support any specific therapies; however, there are a number of agents, which were used during the SARS epidemic of 2003. It is possible that these might be active against the related MERS coronavirus. We have reviewed the literature on the safety and efficacy of therapies used in patients with SARS with a view to their potential use in patients with MERS-CoV infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albarrak, A M" uniqKey="Albarrak A">A.M. AlBarrak</name></author><author><name sortKey="Stephens, G M" uniqKey="Stephens G">G.M. Stephens</name></author><author><name sortKey="Hewson, R" uniqKey="Hewson R">R. Hewson</name></author><author><name sortKey="Memish, Z A" uniqKey="Memish Z">Z.A. 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Lho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Chan, J F" uniqKey="Chan J">J.F. Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H. Tse</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name></author><author><name sortKey="Lau, C C" uniqKey="Lau C">C.C. Lau</name></author><author><name sortKey="Cai, J P" uniqKey="Cai J">J.P. Cai</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Raj, V S" uniqKey="Raj V">V.S. Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H. Mou</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Indiana</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Momattin, Hisham" sort="Momattin, Hisham" uniqKey="Momattin H" first="Hisham" last="Momattin">Hisham Momattin</name></noRegion><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Mohammed, Khurram" sort="Mohammed, Khurram" uniqKey="Mohammed K" first="Khurram" last="Mohammed">Khurram Mohammed</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Zumla, Alimuddin" sort="Zumla, Alimuddin" uniqKey="Zumla A" first="Alimuddin" last="Zumla">Alimuddin Zumla</name></region></country><country name="États-Unis"><region name="Indiana"><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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